Digoxin toxicity in a premature infant: treatment with Fab fragments of digoxin-specific antibodies

The first use of Fab fragments to treat digoxin toxicity in a premature infant with renal failure, 18 h after the onset of severe arrhythmias, is reported with dramatic results. The development of digoxin toxicity in the context of accepted therapeutic dosing to treat heart failure due to a cerebral...

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Veröffentlicht in:	Pediatric cardiology 1985-01, Vol.6 (2), p.91-93
Hauptverfasser:	Presti, S, Friedman, D, Saslow, J, Doyle, E F, Butler, V P, Smith, T W, Haber, E
Format:	Artikel
Sprache:	eng
Schlagworte:	Arrhythmias, Cardiac - chemically induced Arrhythmias, Cardiac - therapy Digoxin - adverse effects Digoxin - immunology Disorders of Sex Development - complications Humans Immunoglobulin Fab Fragments - therapeutic use Infant, Newborn Infant, Premature, Diseases - chemically induced Infant, Premature, Diseases - therapy
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Beschreibung
Zusammenfassung:	The first use of Fab fragments to treat digoxin toxicity in a premature infant with renal failure, 18 h after the onset of severe arrhythmias, is reported with dramatic results. The development of digoxin toxicity in the context of accepted therapeutic dosing to treat heart failure due to a cerebral arteriovenous malformation is discussed.
ISSN:	0172-0643 1432-1971
DOI:	10.1007/BF02282744