Effect of stobadine on stimulated isolated mast cells

Stobadine, an antiarrhythmic drug with antihistaminic properties, did not liberate histamine from mast cells in vitro. Compound 48/80-stimulated histamine liberation and degranulation was decreased in the presence of stobadine in a dose-dependent way. The spontaneous as well as stimulated calcium di...

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Veröffentlicht in:	Agents and Actions 1988-04, Vol.23 (3-4), p.188-190
Hauptverfasser:	Drábiková, K, Pecivová, J, Nosál, R
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Carbolines - pharmacology Histamine Antagonists Histamine Release - drug effects In Vitro Techniques Male Mast Cells - drug effects Mast Cells - immunology p-Methoxy-N-methylphenethylamine - pharmacology Rats Rats, Inbred Strains
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Zusammenfassung:	Stobadine, an antiarrhythmic drug with antihistaminic properties, did not liberate histamine from mast cells in vitro. Compound 48/80-stimulated histamine liberation and degranulation was decreased in the presence of stobadine in a dose-dependent way. The spontaneous as well as stimulated calcium displacement in mast cells was significantly decreased by stobadine. Stobadine most probably possesses a membrane-stabilizing effect on isolated rat mast cells.
ISSN:	0065-4299 1420-908X
DOI:	10.1007/BF02142536