Differential effects of calcium channel blockers on the responses of the rat vas deferens to intramural nerve stimulation and exogenous drugs

The calcium channel blockers, nifedipine and verapamil, have separate effects on the phases of nerve-induced twitches which are not reflected by their actions on the responses to exogenous NA, ATP and the stable ATP analogue, alpha, beta-mATP. This implies that different calcium channels are used ac...

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Veröffentlicht in:	Experientia 1986-04, Vol.42 (4), p.410-412
Hauptverfasser:	AMOBI, N. I. B, SMITH, I. C. H
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Triphosphate - pharmacology Animals Biological and medical sciences calcium antagonists Calcium Channel Blockers - pharmacology Dogs Epididymis Fundamental and applied biological sciences. Psychology In Vitro Techniques Male Muscle Contraction - drug effects Muscle, Smooth - physiology Norepinephrine - pharmacology Prazosin - pharmacology rats Striated muscle. Tendons vas deferens Vas Deferens - drug effects Vas Deferens - innervation Vas Deferens - physiology Vertebrates: osteoarticular system, musculoskeletal system
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Beschreibung
Zusammenfassung:	The calcium channel blockers, nifedipine and verapamil, have separate effects on the phases of nerve-induced twitches which are not reflected by their actions on the responses to exogenous NA, ATP and the stable ATP analogue, alpha, beta-mATP. This implies that different calcium channels are used according to the manner of stimulation.
ISSN:	0014-4754 1420-9071
DOI:	10.1007/BF02118633