Formation of GABA via oxidative deamination of putrescine in ovaries of immature rats after gonadotrophin stimulation

The diamine oxidase catalyzed metabolism of 14C-putrescine was studied in the ovaries of immature rats with and without stimulation by gonadotrophin. This stimulation resulted in a statistically significant increase in the deamination rate of putrescine with a very predominant production of gamma-am...

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Veröffentlicht in:	Agents and Actions 1980-04, Vol.10 (1 Pt 2), p.106-107
Hauptverfasser:	Andersson, A C, Henningsson, S, von Schéele, C
Format:	Artikel
Sprache:	eng
Schlagworte:	Amine Oxidase (Copper-Containing) - antagonists & inhibitors Amine Oxidase (Copper-Containing) - metabolism Animals Female gamma-Aminobutyric Acid - metabolism Gonadotropins, Equine - pharmacology In Vitro Techniques Monoamine Oxidase Inhibitors - pharmacology Ovary - enzymology Putrescine - metabolism Rats
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Zusammenfassung:	The diamine oxidase catalyzed metabolism of 14C-putrescine was studied in the ovaries of immature rats with and without stimulation by gonadotrophin. This stimulation resulted in a statistically significant increase in the deamination rate of putrescine with a very predominant production of gamma-aminobutyric acid. No formation of polyamines was observed which indicated an importance of putrescine or of products of its oxidative deamination during this cellular activity.
ISSN:	0065-4299 1420-908X
DOI:	10.1007/BF02024189