Effects of oral contraceptive steroids (norethisterone/mestranol) on the activities of hepatic drug-metabolizing enzymes in iron-deficient anemic rats

Either oral contraceptive steroid (norethisterone/mestranol; N/M) treatment or iron-deficiency (Fe(-] anemia alone caused an increase in NADPH cytochrome c reductase and in three hepatic microsomal mixed-function oxidase activities in female rats. When N/M treatment and the Fe(-) diet are combined,...

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Veröffentlicht in:	Experientia 1985-06, Vol.41 (6), p.734-736
Hauptverfasser:	Mizokami, K, Suzuki, K, Inoue, K, Sunouchi, M, Hirakawa, S, Goto, S, Takanaka, A, Kanke, Y
Format:	Artikel
Sprache:	eng
Schlagworte:	Aminopyrine - metabolism Anemia, Hypochromic - enzymology Animals Benzo(a)pyrene - metabolism Biological and medical sciences Birth control Cytochrome P-450 Enzyme System - metabolism Female Gynecology. Andrology. Obstetrics Hexobarbital - metabolism Hormonal contraception iron deficiency anemia Medical sciences Mestranol - pharmacology metabolism Microsomes, Liver - drug effects Microsomes, Liver - enzymology Mixed Function Oxygenases - metabolism NADPH-Ferrihemoprotein Reductase - metabolism Norethindrone - pharmacology oral contraceptives Rats Rats, Inbred Strains
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Zusammenfassung:	Either oral contraceptive steroid (norethisterone/mestranol; N/M) treatment or iron-deficiency (Fe(-] anemia alone caused an increase in NADPH cytochrome c reductase and in three hepatic microsomal mixed-function oxidase activities in female rats. When N/M treatment and the Fe(-) diet are combined, no further change in hepatic enzyme activity is seen compared with that with either treatment alone.
ISSN:	0014-4754 1420-9071
DOI:	10.1007/bf02012571