Mutagenicity and toxicity of chloroethylene oxide and chloroacetaldehyde

Exposure of several trp-auxotrophic Escherichia coli strains, carrying base-pair substitutions, to chloroethylene oxide or chloroacetaldehyde (two metabolites of vinyl chloride) increased the mutation frequency to tryptophan prototrophy. Strong cytotoxic and mutagenic effects were observed with 2.5...

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Veröffentlicht in:	Experientia 1985-01, Vol.41 (5), p.676-677
1. Verfasser:	Perrard, M H
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetaldehyde - analogs & derivatives Acetaldehyde - toxicity Escherichia coli Escherichia coli - drug effects Escherichia coli - genetics Ethylene Oxide - analogs & derivatives Ethylene Oxide - toxicity Mutagens Tryptophan - genetics
Online-Zugang:	Volltext
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