Mutagenicity and toxicity of chloroethylene oxide and chloroacetaldehyde

Exposure of several trp-auxotrophic Escherichia coli strains, carrying base-pair substitutions, to chloroethylene oxide or chloroacetaldehyde (two metabolites of vinyl chloride) increased the mutation frequency to tryptophan prototrophy. Strong cytotoxic and mutagenic effects were observed with 2.5...

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Veröffentlicht in:	Experientia 1985-01, Vol.41 (5), p.676-677
1. Verfasser:	Perrard, M H
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetaldehyde - analogs & derivatives Acetaldehyde - toxicity Escherichia coli Escherichia coli - drug effects Escherichia coli - genetics Ethylene Oxide - analogs & derivatives Ethylene Oxide - toxicity Mutagens Tryptophan - genetics
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Zusammenfassung:	Exposure of several trp-auxotrophic Escherichia coli strains, carrying base-pair substitutions, to chloroethylene oxide or chloroacetaldehyde (two metabolites of vinyl chloride) increased the mutation frequency to tryptophan prototrophy. Strong cytotoxic and mutagenic effects were observed with 2.5 mM chloroethylene oxide, while a higher concentration of chloroacetaldehyde (100 mM) exhibited a mutagenic effect which was 400 times lower.
ISSN:	0014-4754 1420-9071
DOI:	10.1007/BF02007715