[2-o-Iodotyrosine]-oxytocin and [2-o-methyltyrosine]-oxytocin: basic pharmacology and comments on their potential use in binding studies

[2-o-Iodotyrosine]-oxytocin and [2-o-methyltyrosine]-oxytocin: basic pharmacology and comments on their potential use in binding studies

Both [2-o-iodotyrosine]-oxytocin and [2-o-methyltyrosine]-oxytocin display only weak vasopressor and antidiuretic effects on rats. They inhibit the in vitro uterotonic action of oxytocin; this inhibition is not fully competitive. It is concluded that they are not suitable as markers for studies of u...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Experientia 1977-03, Vol.33 (3), p.367-369
Hauptverfasser: Pliska, V, Marbach, P, Vasák, J, Rudinger, J
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Blood Pressure - drug effects
Diuresis - drug effects
Estrus
Female
Magnesium - pharmacology
Male
Oxytocin - analogs & derivatives
Oxytocin - metabolism
Oxytocin - pharmacology
Pregnancy
Rats
Uterine Contraction - drug effects
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:Both [2-o-iodotyrosine]-oxytocin and [2-o-methyltyrosine]-oxytocin display only weak vasopressor and antidiuretic effects on rats. They inhibit the in vitro uterotonic action of oxytocin; this inhibition is not fully competitive. It is concluded that they are not suitable as markers for studies of uterine receptor for oxytocin.
ISSN:0014-4754
1420-9071
DOI:10.1007/BF02002831