Characteristics of deoxycholic acid-induced histamine release from mast cells of guinea-pig rectocolonic mucosa and rat peritoneal cavity

Deoxycholic acid (DA) caused a dose-related release of histamine (HR) from mast cells of rat peritoneum (RPMC) and mucosal cells of guinea pig rectocolon (RCMC). In both cell populations, DA-induced HR was: (1) accompared by a parallel release of lactate dehydrogenase (LDH), (2) not affected by meta...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Agents and Actions 1991-05, Vol.33 (1-2), p.76-80
Hauptverfasser:	Peh, K H, Wan, B Y, Assem, E S
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Colon - cytology Deoxycholic Acid - pharmacology Female Guinea Pigs Histamine Release - drug effects Hydrogen-Ion Concentration Intestinal Mucosa - cytology Kinetics L-Lactate Dehydrogenase - metabolism Male Mast Cells - drug effects Mast Cells - physiology Peritoneal Cavity - cytology Rats Rats, Inbred Strains Rectum - cytology Temperature
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Deoxycholic acid (DA) caused a dose-related release of histamine (HR) from mast cells of rat peritoneum (RPMC) and mucosal cells of guinea pig rectocolon (RCMC). In both cell populations, DA-induced HR was: (1) accompared by a parallel release of lactate dehydrogenase (LDH), (2) not affected by metabolic inhibitors, (3) dependent on time of incubation, temperature and pH, and affected by Ca++ concentration in RPMC but not in RCMC. DA-induced HR from RCMC may be involved in certain functional disorders of the colon.
ISSN:	0065-4299 1420-908X
DOI:	10.1007/BF01993131