Antischistosomal and some toxicological properties of a nitrodiphenylaminoisothiocyanate (C 9333-Go/CGP 4540)

A procedure to enhance the schistosomicidal effectiveness in vivo of an isothiocyanate derivative and some of its antischistosomal properties are reported. Determinations of the effects of this compound on tissue thiol levels and on highly sensitivity bacterial tester strains have indicated that its...

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Veröffentlicht in:	Experientia 1976-01, Vol.32 (5), p.604-606
Hauptverfasser:	Bueding, E, Batzinger, R, Petterson, G
Format:	Artikel
Sprache:	eng
Schlagworte:	Aniline Compounds - therapeutic use Animals Diphenylamine - analogs & derivatives Diphenylamine - therapeutic use Drug Administration Schedule Intestines - microbiology Mice Mutagens - urine Mutation - drug effects Salmonella - drug effects Schistosoma mansoni Schistosomiasis - drug therapy Schistosomicides Sulfathiazoles - therapeutic use Thiocyanates - therapeutic use
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Beschreibung
Zusammenfassung:	A procedure to enhance the schistosomicidal effectiveness in vivo of an isothiocyanate derivative and some of its antischistosomal properties are reported. Determinations of the effects of this compound on tissue thiol levels and on highly sensitivity bacterial tester strains have indicated that its mutagenic potential is of a low order and that the latter is decreased further after reduction of the host's intestinal bacterial flora.
ISSN:	0014-4754 1420-9071
DOI:	10.1007/bf01990188