Effects of macrolide antibiotics on barbiturate sleeping time in mice
Triacetyloleandomycin and josamycin, when administered to inbred Balb/c mice orally twice daily at a dose of 12.5 or 25 mg per kg over 3 days, were found to increase barbiturate sleeping time significantly. In contrast, erythromycin ethylsuccinate, erythromycin propionate, midecamycin and spiramycin...
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| Veröffentlicht in: | Experientia 1983-01, Vol.39 (12), p.1389-1390 |
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| creator | DESCOTES, J EVREUX, J. C |
| description | Triacetyloleandomycin and josamycin, when administered to inbred Balb/c mice orally twice daily at a dose of 12.5 or 25 mg per kg over 3 days, were found to increase barbiturate sleeping time significantly. In contrast, erythromycin ethylsuccinate, erythromycin propionate, midecamycin and spiramycin were devoid of any such activity under the same conditions. |
| doi_str_mv | 10.1007/BF01990119 |
| format | Article |
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| fulltext | fulltext |
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| ispartof | Experientia, 1983-01, Vol.39 (12), p.1389-1390 |
| issn | 0014-4754 1420-9071 |
| language | eng |
| recordid | cdi_crossref_primary_10_1007_BF01990119 |
| source | MEDLINE; SpringerLink Journals |
| subjects | Animals Antibacterial agents Antibiotics. Antiinfectious agents. Antiparasitic agents Biological and medical sciences Drug Interactions Female Leucomycins - pharmacology Male Medical sciences Mice Mice, Inbred BALB C Pentobarbital - pharmacology Pharmacology. Drug treatments Sleep - drug effects Time Factors Troleandomycin - pharmacology |
| title | Effects of macrolide antibiotics on barbiturate sleeping time in mice |
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