Effects of macrolide antibiotics on barbiturate sleeping time in mice

Effects of macrolide antibiotics on barbiturate sleeping time in mice

Triacetyloleandomycin and josamycin, when administered to inbred Balb/c mice orally twice daily at a dose of 12.5 or 25 mg per kg over 3 days, were found to increase barbiturate sleeping time significantly. In contrast, erythromycin ethylsuccinate, erythromycin propionate, midecamycin and spiramycin...

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Veröffentlicht in:Experientia 1983-01, Vol.39 (12), p.1389-1390
Hauptverfasser: DESCOTES, J, EVREUX, J. C
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Antibacterial agents
Antibiotics. Antiinfectious agents. Antiparasitic agents
Biological and medical sciences
Drug Interactions
Female
Leucomycins - pharmacology
Male
Medical sciences
Mice
Mice, Inbred BALB C
Pentobarbital - pharmacology
Pharmacology. Drug treatments
Sleep - drug effects
Time Factors
Troleandomycin - pharmacology
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Zusammenfassung:Triacetyloleandomycin and josamycin, when administered to inbred Balb/c mice orally twice daily at a dose of 12.5 or 25 mg per kg over 3 days, were found to increase barbiturate sleeping time significantly. In contrast, erythromycin ethylsuccinate, erythromycin propionate, midecamycin and spiramycin were devoid of any such activity under the same conditions.
ISSN:0014-4754
1420-9071
DOI:10.1007/BF01990119