Stimulation of cyclo-oxygenase by lidocaine, a pro-lipoperoxidant

Lidocaine, which was recently demonstrated to be a good pro-lipoperoxidant, was tested on in vitro PGs biosynthesis, and on arachidonate-induced arterial hypotension, in the rabbit. In the in vitro experiments, lidocaine alone was a poor stimulant of cyclo-oxygenase, but it enhanced significantly th...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Experientia 1983-12, Vol.39 (12), p.1364-1366
Hauptverfasser:	DEBY, C, DEBY-DUPONT, G, HANS, P, PINCEMAIL, J, BOURDON-NEURAY, J
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Arachidonic Acid Arachidonic Acids - pharmacology Biological and medical sciences Blood Pressure - drug effects Cattle Dose-Response Relationship, Drug Drug Synergism Enzyme Activation - drug effects General and cellular metabolism. Vitamins Lidocaine - pharmacology Male Medical sciences Pharmacology. Drug treatments Prostaglandin-Endoperoxide Synthases - metabolism Prostaglandins - biosynthesis Rabbits Seminal Vesicles - enzymology Uric Acid - pharmacology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Lidocaine, which was recently demonstrated to be a good pro-lipoperoxidant, was tested on in vitro PGs biosynthesis, and on arachidonate-induced arterial hypotension, in the rabbit. In the in vitro experiments, lidocaine alone was a poor stimulant of cyclo-oxygenase, but it enhanced significantly the cyclo-oxygenase activation of uric acid. In the rabbit, lidocaine lowered the i.v. arachidonate dose necessary to obtain a significant drop of blood pressure.
ISSN:	0014-4754 1420-9071
DOI:	10.1007/BF01990106