Model systems demonstrating the volatile mutagenicity and carcinogenicity of sodium nitrite in rats

Model systems demonstrating the volatile mutagenicity and carcinogenicity of sodium nitrite in rats

Volatile mutagens derived from sodium nitrite buffered at various pH values or in the presence of human feces were detected using Ames Salmonella tester strain TA 1535 on petrie plates inverted over samples. Volatile mutagenicity increased as the pH decreased and was primarily a function of the nitr...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Experientia 1984-06, Vol.40 (6), p.554-557
Hauptverfasser: MACDONALD, I. A, MADER, J. A, RAO, B. G, MALATJALIAN, D. A
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Biological and medical sciences
Carcinogens - pharmacology
Catheters, Indwelling
Cecum
Chemical mutagenesis
Feces
Humans
Hydrogen-Ion Concentration
Male
Medical sciences
Models, Biological
Mutagens - pharmacology
Nitrites - pharmacology
Rats
Rats, Inbred Strains
Salmonella
Sodium Nitrite - administration & dosage
Sodium Nitrite - pharmacology
Toxicology
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:Volatile mutagens derived from sodium nitrite buffered at various pH values or in the presence of human feces were detected using Ames Salmonella tester strain TA 1535 on petrie plates inverted over samples. Volatile mutagenicity increased as the pH decreased and was primarily a function of the nitrous acid produced from sodium nitrite and hydrogen ions. Sodium nitrite administered intracecally to 3 Wistar rats through surgically implanted cannula caused tumors (fibrosarcoma: 1/3 and squamous cell, 2/3). The possible role of nitrite-derived mutagens in GI cancer is discussed.
ISSN:0014-4754
1420-9071
DOI:10.1007/BF01982327