Histopathological modifications following immunotherapy with P 40 in rats bearing DMBA-induced mammary carcinoma

Female Sprague-Dawley rats bearing primarily-induced mammary carcinomas were treated with a new immunostimulating agent (P 40). The histopathological modifications encountered in tumors, lymph nodes, liver and spleen are described. Intratumoral injections provoke a more widespread response of the RE...

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Veröffentlicht in:	Experientia 1980-10, Vol.36 (10), p.1213-1215
Hauptverfasser:	Hollmann, K H, Verley, J M
Format:	Artikel
Sprache:	eng
Schlagworte:	9,10-Dimethyl-1,2-benzanthracene Adjuvants, Immunologic - therapeutic use Animals Corynebacterium Female Immunotherapy Mammary Neoplasms, Experimental - drug therapy Mammary Neoplasms, Experimental - immunology Mammary Neoplasms, Experimental - pathology Rats
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Zusammenfassung:	Female Sprague-Dawley rats bearing primarily-induced mammary carcinomas were treated with a new immunostimulating agent (P 40). The histopathological modifications encountered in tumors, lymph nodes, liver and spleen are described. Intratumoral injections provoke a more widespread response of the RES, and particularly a more intense reaction in the draining lymph nodes, than systemic treatment.
ISSN:	0014-4754 1420-9071
DOI:	10.1007/BF01976136