Stimulation of pyruvate carboxylation by gastric secretagogues

Stimulation of pyruvate carboxylation by gastric secretagogues

Pyruvate carboxylation was stimulated by 2 gastric secretagogues, histamine and dibutyryl cyclic AMP, and by butyrate. Thiocyanate, an inhibitor of acid secretion, produced a slight decrease. Avidin significantly reduced acid secretion and this effect was overcome by biotin and oxalacetate. The resu...

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Veröffentlicht in:Experientia 1980-10, Vol.36 (10), p.1198-1199
Hauptverfasser: de Bohórquez, E, Chacín, J
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Avidin - pharmacology
Biotin - pharmacology
Bucladesine - pharmacology
Bufo marinus
Butyrates - pharmacology
Gastric Mucosa - drug effects
Gastric Mucosa - metabolism
Histamine - pharmacology
Pyruvates - metabolism
Thiocyanates - pharmacology
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Zusammenfassung:Pyruvate carboxylation was stimulated by 2 gastric secretagogues, histamine and dibutyryl cyclic AMP, and by butyrate. Thiocyanate, an inhibitor of acid secretion, produced a slight decrease. Avidin significantly reduced acid secretion and this effect was overcome by biotin and oxalacetate. The results suggest that carboxylation of pyruvate is one of the reactions controlling oxidative metabolism and acid secretion in toad gastric mucosa.
ISSN:0014-4754
1420-9071
DOI:10.1007/BF01976126