Regression of genetically determined polycystic kidney disease in murine organ culture

Cystic kidneys from the mutant CPK strain of C57BL/6J mice were cultured in serum-free organ culture. During 120 h of incubation in chemically-defined medium, CPK cystic tubular changes underwent complete regression. Environmental factors regulate the expression of genetically determined polycystic...

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Veröffentlicht in:	Experientia 1986-01, Vol.42 (1), p.77-80
Hauptverfasser:	AVNER, E. D, SWEENEY, W. E. JR, PIESCO, N. P, ELLIS, D
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Cell Survival Culture Media Kidney - pathology Kidney Glomerulus - pathology Kidney Tubules - pathology Kidneys Malformations of the urinary system Medical sciences Mice Mice, Inbred C57BL Mice, Mutant Strains Nephrology. Urinary tract diseases Organ Culture Techniques Polycystic Kidney Diseases - genetics Polycystic Kidney Diseases - pathology Time Factors
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Zusammenfassung:	Cystic kidneys from the mutant CPK strain of C57BL/6J mice were cultured in serum-free organ culture. During 120 h of incubation in chemically-defined medium, CPK cystic tubular changes underwent complete regression. Environmental factors regulate the expression of genetically determined polycystic kidney disease in this model.
ISSN:	0014-4754 1420-9071
DOI:	10.1007/BF01975904