Increase of collagen synthesis in pulmonary arteries of monocrotaline-treated rats

Collagen synthesis in the pulmonary artery in animals with pulmonary hypertension was studied using monocrotaline-treated rats as a model. Incorporation of 14C-lateled proline into collagenase-digestible protein in the pulmonary artery was found to be 4-5 times higher in monocrotaline-treated rats t...

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Veröffentlicht in:	Experientia 1980-04, Vol.36 (4), p.441-442
Hauptverfasser:	Kameji, R, Otsuka, H, Hayashi, Y
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Aorta - drug effects Aorta - metabolism Collagen - biosynthesis Male Monocrotaline Pulmonary Artery - drug effects Pulmonary Artery - metabolism Pyrrolizidine Alkaloids - pharmacology Rats
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Zusammenfassung:	Collagen synthesis in the pulmonary artery in animals with pulmonary hypertension was studied using monocrotaline-treated rats as a model. Incorporation of 14C-lateled proline into collagenase-digestible protein in the pulmonary artery was found to be 4-5 times higher in monocrotaline-treated rats than in control rats.
ISSN:	0014-4754 1420-9071
DOI:	10.1007/BF01975136