Studies on the biochemical effects of glibenclamide on alloxan diabetic rabbits

Treatment of alloxan diabetic rabbits with glibenclamide, the most potent of the sulfonylureas, for a period of 2 months, significantly ameliorated the diabetic condition. It produced a decrease in serum and liver lipids, amino acids, serum urea, blood sugar and urine sugar; increase in body weight,...

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Veröffentlicht in:	Experientia 1980-04, Vol.36 (4), p.383-384
Hauptverfasser:	Annamala, P T, Augusti, K T
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Blood Glucose - metabolism Body Weight - drug effects Diabetes Mellitus, Experimental - physiopathology Glyburide - pharmacology Glycosuria Lipid Metabolism Lipids - blood Liver - metabolism Male Phosphates - blood Phosphates - metabolism Rabbits
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Zusammenfassung:	Treatment of alloxan diabetic rabbits with glibenclamide, the most potent of the sulfonylureas, for a period of 2 months, significantly ameliorated the diabetic condition. It produced a decrease in serum and liver lipids, amino acids, serum urea, blood sugar and urine sugar; increase in body weight, serum and liver proteins, liver glycogen, glucose tolerance and serum and liver acid labile phosphates. The possible mechanism of action of this hypoglycemic agent is discussed.
ISSN:	0014-4754 1420-9071
DOI:	10.1007/BF01975099