Neutrophilic granulocytosis following lead acetate in female mice

Lead induces an abrupt neutrophilic granulocytosis with the peak response detected 4 days after treatment. Using the incorporation of tritiated thymidine as an index of neutrophil production, autoradiographic analysis revealed that only about 16% of the total neutrophil increase is associated with a...

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Veröffentlicht in:	Experientia 1985-07, Vol.41 (7), p.942-943
1. Verfasser:	HOGAN, G. R
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Cell Division Chemical and industrial products toxicology. Toxic occupational diseases Female Lead Poisoning - pathology Medical sciences Metals and various inorganic compounds Mice Myeloproliferative Disorders - chemically induced Neutrophils - pathology Time Factors Toxicology
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Zusammenfassung:	Lead induces an abrupt neutrophilic granulocytosis with the peak response detected 4 days after treatment. Using the incorporation of tritiated thymidine as an index of neutrophil production, autoradiographic analysis revealed that only about 16% of the total neutrophil increase is associated with a stimulatory effect on production. The remainder of the increase appears to be linked to the panhistotoxic action of lead, promoting migration of neutrophils from reserve sites in the wake of tissue damage.
ISSN:	0014-4754 1420-9071
DOI:	10.1007/BF01970024