α-particle track autoradiographic study of the distribution of a [211At]-astatinated drug in normal tissues of the mouse

The microscopic distribution of the potential endoradiotherapeutic drug, 6-[211At]-astato-2-methyl-1,4- naphthoquinol bis (diphosphate salt) in normal tissues of the mouse has been studied by alpha-particle track autoradiography. The uptake into critical radiosensitive tissues, especially bone marro...

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Veröffentlicht in:	Experientia 1985-07, Vol.41 (7), p.925-928
Hauptverfasser:	MITCHELL, J. S, BROWN, I, CARPENTER, R. N
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Agents - metabolism Astatine - metabolism Autoradiography Biological and medical sciences Bone Marrow - metabolism Colon - metabolism Contrast media. Radiopharmaceuticals Lung - metabolism Male Medical sciences Mice Mice, Inbred C57BL Pharmacology. Drug treatments Rats Tissue Distribution Vitamin K - analogs & derivatives Vitamin K - metabolism Vitamin K 3 - analogs & derivatives
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Beschreibung
Zusammenfassung:	The microscopic distribution of the potential endoradiotherapeutic drug, 6-[211At]-astato-2-methyl-1,4- naphthoquinol bis (diphosphate salt) in normal tissues of the mouse has been studied by alpha-particle track autoradiography. The uptake into critical radiosensitive tissues, especially bone marrow, colon and lung, was low.
ISSN:	0014-4754 1420-9071
DOI:	10.1007/BF01970016