Salazopyrin in rheumatoid arthritis

After a 12-week preliminary period of observation 32 patients with consistently active rheumatoid arthritis (RA) were treated for up to 22 weeks with salazopyrin. Seven patients could not tolerate the drug. The remaining 25 patients had a marked improvement in subjective clinical state and significa...

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Veröffentlicht in:	Agents and Actions 1978-06, Vol.8 (4), p.438-441
Hauptverfasser:	McConkey, B, Amos, R S, Butler, E P, Crockson, R A, Crockson, A P, Walsh, L
Format:	Artikel
Sprache:	eng
Schlagworte:	Arthritis, Rheumatoid - blood Arthritis, Rheumatoid - drug therapy Blood Sedimentation C-Reactive Protein - metabolism Female Humans Male Middle Aged Sulfasalazine - adverse effects Sulfasalazine - therapeutic use
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Zusammenfassung:	After a 12-week preliminary period of observation 32 patients with consistently active rheumatoid arthritis (RA) were treated for up to 22 weeks with salazopyrin. Seven patients could not tolerate the drug. The remaining 25 patients had a marked improvement in subjective clinical state and significant falls in serum C-reactive protein and the erythrocyte sedimentation rate 6 weeks after treatment began. The improvement was maintained after 22 weeks. The results strongly suggest that further trials with this drug in RA are needed.
ISSN:	0065-4299 1420-908X
DOI:	10.1007/BF01968673