Hageman factor activation and tight junction disruption in mice challenged with attenuated endotoxin

Hageman factor activation and tight junction disruption in mice challenged with attenuated endotoxin

Endotoxin treated with chromium chloride is less toxic to mice than the parent molecule, but can disrupt intestinal permeability barriers and has an enhanced ability to activate Hageman factor.

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Bibliographische Detailangaben
Veröffentlicht in:Experientia 1979-06, Vol.35 (6), p.759-762
Hauptverfasser: Walker, R.I, Porvaznik, M, Egan, J.E, Miller, A.M
Format: Artikel
Sprache:eng
Schlagworte:
animal health
animal injuries
Animals
Chromium - pharmacology
Endotoxins - antagonists & inhibitors
Endotoxins - toxicity
Epithelium - ultrastructure
Factor XII - metabolism
Ileum - drug effects
Ileum - ultrastructure
Intercellular Junctions - drug effects
Lipopolysaccharides - pharmacology
Male
Mice
Permeability
Salmonella typhi
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Zusammenfassung:Endotoxin treated with chromium chloride is less toxic to mice than the parent molecule, but can disrupt intestinal permeability barriers and has an enhanced ability to activate Hageman factor.
ISSN:0014-4754
1420-9071
DOI:10.1007/BF01968230