The antipyretic effect of UP 517-03 in the rabbit

The antipyretic effect of UP 517-03 in the rabbit

The antipyretic effect of UP 517-03 was studied in rabbits, provided with a cannula in the lateral cerebral ventricle. Given orally as a curative treatment, UP 517-03 can abolish hyperthermic reactions induced by intracerebroventricular injection of sodium arachidonate or bacterial endotoxin. A comp...

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Veröffentlicht in:Agents and Actions 1979-12, Vol.9 (5-6), p.516-520
Hauptverfasser: Hertz, F, Chevrier, M M, Dumeur, G, Lwoff, J M
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Anti-Inflammatory Agents, Non-Steroidal
Arachidonic Acids - antagonists & inhibitors
Aspirin - pharmacology
Body Temperature - drug effects
Endotoxins - antagonists & inhibitors
Indans - pharmacology
Indenes - pharmacology
Indomethacin - pharmacology
Male
Propionates - pharmacology
Rabbits
Salmonella
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Zusammenfassung:The antipyretic effect of UP 517-03 was studied in rabbits, provided with a cannula in the lateral cerebral ventricle. Given orally as a curative treatment, UP 517-03 can abolish hyperthermic reactions induced by intracerebroventricular injection of sodium arachidonate or bacterial endotoxin. A comparison with acetylsalicylic acid and indomethacin is given. UP 517-03 does not modify the temperature of normothermic rabbits. These results suggests that the antipyretic action of UP 517-03 can be explained by an effect of this substance on the metabolism of arachidonic acid in brain.
ISSN:0065-4299
1420-908X
DOI:10.1007/BF01968121