Role of neurotransmitter release and cyclic AMP-dependent membrane phosphorylation in low voltage myocardial automaticity

Low voltage myocardial automaticity (LVA) was investigated by pharmacological modulations of the presynaptic and postsynaptic processes. The sensitivity of LVA both to inhibitor and stimulator of neurotransmitter release suggests its involvement in LVA genesis. Moreover, LVA is blocked by the inhibi...

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Veröffentlicht in:	Experientia 1981-07, Vol.37 (7), p.731-734
Hauptverfasser:	Saxon, M E, Safronova, V G, Lazarev, A V, Freidin, A A, Kokoz, Y M
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Alprenolol - pharmacology Animals Cell Membrane - metabolism Cyclic AMP - pharmacology Electrophysiology Heterocyclic Compounds - pharmacology Humans Imines - pharmacology Myocardial Contraction - drug effects Neurotransmitter Agents - metabolism Oxymetazoline - pharmacology Papillary Muscles - physiology Phosphorylation Rabbits Tolbutamide - pharmacology Tyramine - pharmacology
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Beschreibung
Zusammenfassung:	Low voltage myocardial automaticity (LVA) was investigated by pharmacological modulations of the presynaptic and postsynaptic processes. The sensitivity of LVA both to inhibitor and stimulator of neurotransmitter release suggests its involvement in LVA genesis. Moreover, LVA is blocked by the inhibition of the cyclic AMP system, supporting the participation of the c-AMP-dependent membrane phosphorylation in calcium-mediated cardiac electrogenesis.
ISSN:	0014-4754 1420-9071
DOI:	10.1007/BF01967949