Chemiluminescence response of human blood mononuclear cells to PHA and histamine

Chemiluminescence response of human blood mononuclear cells to PHA and histamine

Phytohaemagglutinin (PHA) elicited a short early chemiluminescence (CL) response of human blood mononuclear cells with a maximum at 2.5 min. The magnitude of the CL production was a function of the PHA concentration used. The CL response could be dose-dependently inhibited by histamine. In the prese...

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Veröffentlicht in:Agents and Actions 1983-04, Vol.13 (2-3), p.237-240
Hauptverfasser: Merétey, K, Böhm, U, Falus, A
Format: Artikel
Sprache:eng
Schlagworte:
Cimetidine - pharmacology
Dose-Response Relationship, Drug
Histamine - pharmacology
Humans
Luminescent Measurements
Lymphocytes - drug effects
Phytohemagglutinins - pharmacology
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Zusammenfassung:Phytohaemagglutinin (PHA) elicited a short early chemiluminescence (CL) response of human blood mononuclear cells with a maximum at 2.5 min. The magnitude of the CL production was a function of the PHA concentration used. The CL response could be dose-dependently inhibited by histamine. In the presence of mepyramine the action of histamine was more pronounced while a dose-dependent reversal of the inhibition was found by cimetidine.
ISSN:0065-4299
1420-908X
DOI:10.1007/BF01967341