The effect of sodium 5,6-dimethyl-2-nitroindanedione on anaphylactic reactions in vitro

A nitroindanedione (BRL 10833) inhibited the antigen induced release of histamine and slow reacting substance of anaphylaxis (SRS-A) from passively sensitized human lung at similar concentrations to those required for the inhibition of histamine release by disodium cromoglycate (DSCG). BRL 10833 was...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Agents and Actions 1978-04, Vol.8 (3), p.199-202
Hauptverfasser:	Sharpe, T J, Ross, J W, Spicer, B A
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigens Cells, Cultured Cromolyn Sodium - pharmacology Histamine Release - drug effects Humans Indans - therapeutic use Indenes - therapeutic use Leukocytes - metabolism Lung - metabolism Male Passive Cutaneous Anaphylaxis - drug effects Rats Skin - drug effects SRS-A - metabolism
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	A nitroindanedione (BRL 10833) inhibited the antigen induced release of histamine and slow reacting substance of anaphylaxis (SRS-A) from passively sensitized human lung at similar concentrations to those required for the inhibition of histamine release by disodium cromoglycate (DSCG). BRL 10833 was more potent than DSCG as an inhibitor of histamine release by antigen from actively and passively sensitized rat peritoneal cells and rat skin fragments.
ISSN:	0065-4299 1420-908X
DOI:	10.1007/BF01966603