3H-tiotidine binding to guinea-pig cortical and striatal membranes
3H-Tiotidine has been identified as a suitable radioligand for the H2-receptor. We have confirmed and extended structure-binding affinity studies in the guinea-pig cortex, and established a structure-binding affinity relationship consistent with the H2-receptor in guinea-pig striatum. Cimetidine-dis...
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| Veröffentlicht in: | Agents and Actions 1986-11, Vol.19 (3-4), p.169-173 |
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| container_end_page | 173 |
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| container_issue | 3-4 |
| container_start_page | 169 |
| container_title | Agents and Actions |
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| creator | Smith, I R Leigh, B K Mylek, M E |
| description | 3H-Tiotidine has been identified as a suitable radioligand for the H2-receptor. We have confirmed and extended structure-binding affinity studies in the guinea-pig cortex, and established a structure-binding affinity relationship consistent with the H2-receptor in guinea-pig striatum. Cimetidine-displaceable 3H-tiotidine binding was observed also in the nucleus accumbens. |
| doi_str_mv | 10.1007/BF01966202 |
| format | Article |
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Cimetidine-displaceable 3H-tiotidine binding was observed also in the nucleus accumbens.</description><identifier>ISSN: 0065-4299</identifier><identifier>EISSN: 1420-908X</identifier><identifier>DOI: 10.1007/BF01966202</identifier><identifier>PMID: 3825739</identifier><language>eng</language><publisher>Switzerland</publisher><subject>Animals ; Cerebral Cortex - metabolism ; Cimetidine - analogs & derivatives ; Cimetidine - metabolism ; Corpus Striatum - metabolism ; Guinea Pigs ; In Vitro Techniques ; Kinetics ; Membranes - metabolism</subject><ispartof>Agents and Actions, 1986-11, Vol.19 (3-4), p.169-173</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c1299-554f5d1445bca7a07756463fe99f011a7e3ff942b1bd9fe80d89809e2b8fcb6e3</citedby><cites>FETCH-LOGICAL-c1299-554f5d1445bca7a07756463fe99f011a7e3ff942b1bd9fe80d89809e2b8fcb6e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3825739$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Smith, I R</creatorcontrib><creatorcontrib>Leigh, B K</creatorcontrib><creatorcontrib>Mylek, M E</creatorcontrib><title>3H-tiotidine binding to guinea-pig cortical and striatal membranes</title><title>Agents and Actions</title><addtitle>Agents Actions</addtitle><description>3H-Tiotidine has been identified as a suitable radioligand for the H2-receptor. We have confirmed and extended structure-binding affinity studies in the guinea-pig cortex, and established a structure-binding affinity relationship consistent with the H2-receptor in guinea-pig striatum. Cimetidine-displaceable 3H-tiotidine binding was observed also in the nucleus accumbens.</description><subject>Animals</subject><subject>Cerebral Cortex - metabolism</subject><subject>Cimetidine - analogs & derivatives</subject><subject>Cimetidine - metabolism</subject><subject>Corpus Striatum - metabolism</subject><subject>Guinea Pigs</subject><subject>In Vitro Techniques</subject><subject>Kinetics</subject><subject>Membranes - metabolism</subject><issn>0065-4299</issn><issn>1420-908X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1986</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkEtLAzEUhYMotVY37oVZuRBGb16TZGmLtULBjYK7IckkJTKPmsws_PdGWnR1uJePw-FD6BrDPQYQD8s1YFVVBMgJmmNGoFQgP07RHKDiJSNKnaOLlD4BOMcSz9CMSsIFVXO0pJtyDMMYmtC7woQ-564Yh2I35Ycu92FX2CGOweq20H1TpDEGPeajc52JunfpEp153SZ3dcwFel8_va025fb1-WX1uC0tzgtKzpnnDWaMG6uFBiF4xSrqnVIeMNbCUe8VIwabRnknoZFKgnLESG9N5egC3R5693H4mlwa6y4k69o2jximVAtBFGGqyuDdAbRxSCk6X-9j6HT8rjHUv8Lqf2EZvjm2TqZzzR96NER_ALN_ZLE</recordid><startdate>198611</startdate><enddate>198611</enddate><creator>Smith, I R</creator><creator>Leigh, B K</creator><creator>Mylek, M E</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>198611</creationdate><title>3H-tiotidine binding to guinea-pig cortical and striatal membranes</title><author>Smith, I R ; Leigh, B K ; Mylek, M E</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c1299-554f5d1445bca7a07756463fe99f011a7e3ff942b1bd9fe80d89809e2b8fcb6e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1986</creationdate><topic>Animals</topic><topic>Cerebral Cortex - metabolism</topic><topic>Cimetidine - analogs & derivatives</topic><topic>Cimetidine - metabolism</topic><topic>Corpus Striatum - metabolism</topic><topic>Guinea Pigs</topic><topic>In Vitro Techniques</topic><topic>Kinetics</topic><topic>Membranes - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Smith, I R</creatorcontrib><creatorcontrib>Leigh, B K</creatorcontrib><creatorcontrib>Mylek, M E</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Agents and Actions</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Smith, I R</au><au>Leigh, B K</au><au>Mylek, M E</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>3H-tiotidine binding to guinea-pig cortical and striatal membranes</atitle><jtitle>Agents and Actions</jtitle><addtitle>Agents Actions</addtitle><date>1986-11</date><risdate>1986</risdate><volume>19</volume><issue>3-4</issue><spage>169</spage><epage>173</epage><pages>169-173</pages><issn>0065-4299</issn><eissn>1420-908X</eissn><abstract>3H-Tiotidine has been identified as a suitable radioligand for the H2-receptor. 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| fulltext | fulltext |
| identifier | ISSN: 0065-4299 |
| ispartof | Agents and Actions, 1986-11, Vol.19 (3-4), p.169-173 |
| issn | 0065-4299 1420-908X |
| language | eng |
| recordid | cdi_crossref_primary_10_1007_BF01966202 |
| source | MEDLINE; Springer Nature - Complete Springer Journals |
| subjects | Animals Cerebral Cortex - metabolism Cimetidine - analogs & derivatives Cimetidine - metabolism Corpus Striatum - metabolism Guinea Pigs In Vitro Techniques Kinetics Membranes - metabolism |
| title | 3H-tiotidine binding to guinea-pig cortical and striatal membranes |
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