3H-tiotidine binding to guinea-pig cortical and striatal membranes

3H-tiotidine binding to guinea-pig cortical and striatal membranes

3H-Tiotidine has been identified as a suitable radioligand for the H2-receptor. We have confirmed and extended structure-binding affinity studies in the guinea-pig cortex, and established a structure-binding affinity relationship consistent with the H2-receptor in guinea-pig striatum. Cimetidine-dis...

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Veröffentlicht in:Agents and Actions 1986-11, Vol.19 (3-4), p.169-173
Hauptverfasser: Smith, I R, Leigh, B K, Mylek, M E
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Cerebral Cortex - metabolism
Cimetidine - analogs & derivatives
Cimetidine - metabolism
Corpus Striatum - metabolism
Guinea Pigs
In Vitro Techniques
Kinetics
Membranes - metabolism
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Zusammenfassung:3H-Tiotidine has been identified as a suitable radioligand for the H2-receptor. We have confirmed and extended structure-binding affinity studies in the guinea-pig cortex, and established a structure-binding affinity relationship consistent with the H2-receptor in guinea-pig striatum. Cimetidine-displaceable 3H-tiotidine binding was observed also in the nucleus accumbens.
ISSN:0065-4299
1420-908X
DOI:10.1007/BF01966202