Collagenase-like peptidase activity in serum from patients with rheumatoid arthritis

The activities of collagenase-like peptidase, estimated by using (succinyl-Gly-Pro-Leu-Gly-Pro-Leu-Gly-Pro)-4-methylcoumaryl-7-amide as substrate, and of dipeptidyl-aminopeptidase IV were decreased in the sera from patients with rheumatoid arthritis. Both enzymes bring about the degradation of pepti...

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Veröffentlicht in:	Experientia 1985-04, Vol.41 (4), p.487-488
Hauptverfasser:	IWASE-OKADA, K, KOJIMA, K, KATO, T, KAKU, H, OKAZAKI, T, WAGO, K, SAKAKIBARA, S, NAGATSU, T
Format:	Artikel
Sprache:	eng
Schlagworte:	Arthritis, Rheumatoid - blood Arthritis, Rheumatoid - enzymology Biological and medical sciences Cerebrovascular Disorders - blood Cerebrovascular Disorders - enzymology Collagen - metabolism Dipeptidyl Peptidase 4 Dipeptidyl-Peptidases and Tripeptidyl-Peptidases - blood Diseases of the osteoarticular system Endopeptidases - blood Humans Inflammatory joint diseases Medical sciences Metalloendopeptidases
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Zusammenfassung:	The activities of collagenase-like peptidase, estimated by using (succinyl-Gly-Pro-Leu-Gly-Pro-Leu-Gly-Pro)-4-methylcoumaryl-7-amide as substrate, and of dipeptidyl-aminopeptidase IV were decreased in the sera from patients with rheumatoid arthritis. Both enzymes bring about the degradation of peptides derived from collagen. A significant positive correlation was observed between the activities of the two serum peptidases.
ISSN:	0014-4754 1420-9071
DOI:	10.1007/BF01966162