A comparison of superoxide production by human eosinophils and neutrophils

A comparison of superoxide production by human eosinophils and neutrophils

Previous studies have demonstrated that human eosinophils have a more active hexose monophosphate shunt than neutrophils. However, measurements of superoxide anion production have been variable. In this study human eosinophils are shown to produce one and a half times as much superoxide as neutrophi...

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Veröffentlicht in:Agents and Actions 1982-10, Vol.12 (4), p.485-488
Hauptverfasser: Learn, D B, Brestel, E P
Format: Artikel
Sprache:eng
Schlagworte:
Cytochrome c Group - metabolism
Eosinophils - metabolism
Humans
In Vitro Techniques
Neutrophils - metabolism
Oxidation-Reduction
Oxygen - biosynthesis
Superoxide Dismutase - metabolism
Superoxides - biosynthesis
Time Factors
Zymosan - pharmacology
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Zusammenfassung:Previous studies have demonstrated that human eosinophils have a more active hexose monophosphate shunt than neutrophils. However, measurements of superoxide anion production have been variable. In this study human eosinophils are shown to produce one and a half times as much superoxide as neutrophils during a 2-h incubation. The rates of production differed only after the first 30 min of incubation. The production was inhibited by superoxide dismutase in a dose-responsive manner.
ISSN:0065-4299
1420-908X
DOI:10.1007/BF01965931