Circadian variation of diazepam acute toxicity in mice

Circadian variation of diazepam acute toxicity in mice

The LD50 of i.p. injected diazepam was determined every 4 h over a 24-h period in albino mice adapted to a 12-h dark/12-h light programmed illumination cycle. Results show that diazepam is more toxic during the light phase of the cycle than during the dark phase and demonstrate circadian variation i...

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Veröffentlicht in:Experientia 1981-01, Vol.37 (1), p.72-73
Hauptverfasser: Ross, F H, Sermons, A L, Owasoyo, J O, Walker, C A
Format: Artikel
Sprache:eng
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Animals
Circadian Rhythm
Diazepam - toxicity
Lethal Dose 50
Male
Mice
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container_title Experientia
container_volume 37
creator Ross, F H
Sermons, A L
Owasoyo, J O
Walker, C A
description The LD50 of i.p. injected diazepam was determined every 4 h over a 24-h period in albino mice adapted to a 12-h dark/12-h light programmed illumination cycle. Results show that diazepam is more toxic during the light phase of the cycle than during the dark phase and demonstrate circadian variation in the toxicity of the compound in mice.
doi_str_mv 10.1007/BF01965577
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subjects Animals
Circadian Rhythm
Diazepam - toxicity
Lethal Dose 50
Male
Mice
title Circadian variation of diazepam acute toxicity in mice
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