Circadian variation of diazepam acute toxicity in mice

The LD50 of i.p. injected diazepam was determined every 4 h over a 24-h period in albino mice adapted to a 12-h dark/12-h light programmed illumination cycle. Results show that diazepam is more toxic during the light phase of the cycle than during the dark phase and demonstrate circadian variation i...

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Veröffentlicht in:	Experientia 1981-01, Vol.37 (1), p.72-73
Hauptverfasser:	Ross, F H, Sermons, A L, Owasoyo, J O, Walker, C A
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Circadian Rhythm Diazepam - toxicity Lethal Dose 50 Male Mice
Online-Zugang:	Volltext
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Zusammenfassung:	The LD50 of i.p. injected diazepam was determined every 4 h over a 24-h period in albino mice adapted to a 12-h dark/12-h light programmed illumination cycle. Results show that diazepam is more toxic during the light phase of the cycle than during the dark phase and demonstrate circadian variation in the toxicity of the compound in mice.
ISSN:	0014-4754 1420-9071
DOI:	10.1007/BF01965577