Reserpine prevents goldthioglucose hypothalamic lesions in mice

Reserpine prevents goldthioglucose hypothalamic lesions in mice

In reserpinized mice the occurrence of goldthioglucose hypothalamic lesions was significantly lower than in control mice. Some protection was also conferred by serotonin-receptor blockers and by treatment with nialamide + DL-alpha-methyldopa, but the protective effect of reserpine was not reversed b...

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Veröffentlicht in:Experientia 1981-01, Vol.37 (1), p.52-53
Hauptverfasser: Briese, E, Murzi, E
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Aurothioglucose - pharmacology
Cinanserin - analogs & derivatives
Cinanserin - pharmacology
Dose-Response Relationship, Drug
Drug Interactions
Gold - pharmacology
Hypothalamus - drug effects
Hypothalamus, Middle - drug effects
Methiothepin - pharmacology
Methyldopa - pharmacology
Mice
Nialamide - pharmacology
Reserpine - pharmacology
Serotonin Antagonists - pharmacology
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Zusammenfassung:In reserpinized mice the occurrence of goldthioglucose hypothalamic lesions was significantly lower than in control mice. Some protection was also conferred by serotonin-receptor blockers and by treatment with nialamide + DL-alpha-methyldopa, but the protective effect of reserpine was not reversed by serotonergic and dopaminergic agonists, alone or in combination, nor by insulin.
ISSN:0014-4754
1420-9071
DOI:10.1007/BF01965564