Histamine release from cord basophils

The IgE- and non-IgE-mediated basophil histamine release (HR) may be influenced by different metabolic pathways in the basophils as well as by extracellular mediators. Products of the 5-lipoxygenase (5-LO) pathway of the arachidonic acid (AA) metabolism enhance human basophil HR. We have recently sh...

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Veröffentlicht in:	Agents and Actions 1990-01, Vol.29 (1-2), p.37-38
Hauptverfasser:	Nolte, H, Herlin, T, Hansen, U S, Fogh, K, Schiøtz, P O
Format:	Artikel
Sprache:	eng
Schlagworte:	Arachidonic Acid Arachidonic Acids - metabolism Basophils - drug effects Basophils - metabolism Fetal Blood - cytology Histamine Release - drug effects Humans Immunoglobulin E - immunology In Vitro Techniques Infant, Newborn
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Beschreibung
Zusammenfassung:	The IgE- and non-IgE-mediated basophil histamine release (HR) may be influenced by different metabolic pathways in the basophils as well as by extracellular mediators. Products of the 5-lipoxygenase (5-LO) pathway of the arachidonic acid (AA) metabolism enhance human basophil HR. We have recently shown that inhibitors of 5-LO decrease and inhibitors of cyclooxygenase (CO) increase IgE-mediated HR. In the present study we have measured HR in cord blood and investigated the effect of drugs affecting AA metabolism.
ISSN:	0065-4299 1420-908X
DOI:	10.1007/BF01964714