Control of growth in the rat thyroid--an example of specific desensitization to trophic hormone stimulation

Control of growth in the rat thyroid--an example of specific desensitization to trophic hormone stimulation

Rat thyroid follicular cells desensitized to the mitogenic action of TSH by prolonged stimulation retain the capacity to respond to the mitogenic stimulus of wounding. The implications for thyroid growth control and neoplasia are discussed.

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Bibliographische Detailangaben
Veröffentlicht in:Experientia 1983-04, Vol.39 (4), p.421-423
Hauptverfasser: Wynford-Thomas, D, Stringer, B M, Harach, H R, Williams, E D
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Male
Mitosis
Rats
Rats, Inbred Strains
Thyroid Gland - drug effects
Thyroid Gland - growth & development
Thyroid Gland - injuries
Thyrotropin - pharmacology
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Zusammenfassung:Rat thyroid follicular cells desensitized to the mitogenic action of TSH by prolonged stimulation retain the capacity to respond to the mitogenic stimulus of wounding. The implications for thyroid growth control and neoplasia are discussed.
ISSN:0014-4754
1420-9071
DOI:10.1007/BF01963160