Cyst formation in metanephric organ culture induced by cis-dichlorodiammineplatinum (II)

A new experimental model of renal tubular cyst formation has been developed in metanephric organ culture. The addition of cis-dichlorodiammineplatinum (II), 50 micrograms/ml, to culture medium induces cystic changes during in vitro nephrogenesis. The model has particular utility in the study of basi...

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Veröffentlicht in:	Experientia 1983-01, Vol.39 (1), p.74-76
Hauptverfasser:	Avner, E D, Sweeney, Jr, W E, Ellis, D
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cisplatin Kidney - embryology Mice Models, Biological Organ Culture Techniques Polycystic Kidney Diseases - chemically induced Polycystic Kidney Diseases - pathology
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Beschreibung
Zusammenfassung:	A new experimental model of renal tubular cyst formation has been developed in metanephric organ culture. The addition of cis-dichlorodiammineplatinum (II), 50 micrograms/ml, to culture medium induces cystic changes during in vitro nephrogenesis. The model has particular utility in the study of basic mechanisms underlying renal tubular cystic changes, as well as the mechanisms by which nephrotoxins may mediate renal tubular injury.
ISSN:	0014-4754 1420-9071
DOI:	10.1007/BF01960636