Alpha-amanitin: inactivation by bovine lactoperoxidase

Alpha-amanitin: inactivation by bovine lactoperoxidase

The principle amatoxin, alpha-amanitin, is found to be extremely sensitive toward lactoperoxidase catalyzed degradation, rather than iodination, of the indole nucleus. Extensive attenuation of inhibitor potency against eukaryotic DNA-dependent RNA polymerase II accompanies the treatment of alpha-ama...

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Veröffentlicht in:Experientia 1979-05, Vol.35 (5), p.589-591
Hauptverfasser: Morris, P.W, Kelley, K.M, Logas, W.G
Format: Artikel
Sprache:eng
Schlagworte:
Amanita phalloides
Amanitins - antagonists & inhibitors
Amanitins - metabolism
Amanitins - pharmacology
Animals
Cattle
Drosophila melanogaster - enzymology
In Vitro Techniques
Lactoperoxidase - metabolism
Lactoperoxidase - pharmacology
Peroxidases - pharmacology
RNA Polymerase II - antagonists & inhibitors
Time Factors
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Beschreibung
Zusammenfassung:The principle amatoxin, alpha-amanitin, is found to be extremely sensitive toward lactoperoxidase catalyzed degradation, rather than iodination, of the indole nucleus. Extensive attenuation of inhibitor potency against eukaryotic DNA-dependent RNA polymerase II accompanies the treatment of alpha-amanitin with lactoperoxidase, iodide and hydrogen peroxide.
ISSN:0014-4754
1420-9071
DOI:10.1007/BF01960335