Enantiomeric cannabinoids: stereospecificity of psychotropic activity

Enantiomeric cannabinoids: stereospecificity of psychotropic activity

The 1,1-dimethylheptyl homolog of (-)-(3R,4R)-7-hydroxy-delta-6- tetrahydrocannabinol (compound II) is highly psychotropic in mice, rats and pigeons. The (+)-(3S,4S) enantiomer (III) was found to be psychotropically inactive at doses up to several thousand times those of the ED50 of (II).

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Bibliographische Detailangaben
Veröffentlicht in:Experientia 1988-09, Vol.44 (9), p.762-764
Hauptverfasser: MECHOULAM, R, FEIGENBAUM, J. J, LANDER, N, SEGAL, M, JARBE, T. U. C, HILTUNEN, A. J, CONSROE, P
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Behavior, Animal - drug effects
Biological and medical sciences
Cannabinoids - chemical synthesis
Cannabinoids - pharmacology
Columbidae
Dose-Response Relationship, Drug
Medical sciences
Miscellaneous
Neuropharmacology
Pharmacology. Drug treatments
Rats
Stereoisomerism
Structure-Activity Relationship
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Zusammenfassung:The 1,1-dimethylheptyl homolog of (-)-(3R,4R)-7-hydroxy-delta-6- tetrahydrocannabinol (compound II) is highly psychotropic in mice, rats and pigeons. The (+)-(3S,4S) enantiomer (III) was found to be psychotropically inactive at doses up to several thousand times those of the ED50 of (II).
ISSN:0014-4754
1420-9071
DOI:10.1007/bf01959156