Effect of an antiglucocorticoid (RU-38486) on hydrocortisone induction of maltase-glucosamylase, sucrase-isomaltase and trehalase in brush border membranes of suckling rats

Induction of alpha-glycosidases by hydrocortisone in suckling rats is inhibited by the daily administration of an antiglucocorticoid (RU-38486). Conversely, RU-38486 injected daily in 15-day-old rats for 7 days does not prevent the spontaneous development of alpha-glycosidases.

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Bibliographische Detailangaben
Veröffentlicht in:	Experientia 1988-06, Vol.44 (6), p.516-518
1. Verfasser:	Galand, G
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Animals, Suckling - metabolism brush border membranes enzymes Estrenes - pharmacology Female Glucan 1,4-alpha-Glucosidase - biosynthesis glucocorticoids Glucocorticoids - antagonists & inhibitors Glucosidases - biosynthesis Hydrocortisone - pharmacology Intestine, Small - drug effects Intestine, Small - enzymology Intestine, Small - growth & development Male Microvilli - enzymology Mifepristone Multienzyme Complexes - biosynthesis Rats Rats, Inbred Strains Sucrase-Isomaltase Complex - biosynthesis Trehalase - biosynthesis
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Beschreibung
Zusammenfassung:	Induction of alpha-glycosidases by hydrocortisone in suckling rats is inhibited by the daily administration of an antiglucocorticoid (RU-38486). Conversely, RU-38486 injected daily in 15-day-old rats for 7 days does not prevent the spontaneous development of alpha-glycosidases.
ISSN:	0014-4754 1420-9071
DOI:	10.1007/BF01958934