Two novel prolactin release-inhibiting 8 alpha-amino-ergolines

Prolactin secretion inhibition and changes in striatal dopamine metabolism in rats were compared after the administration of 8 alpha-amino-ergoline CH 29-717 and 2 derivates. CQ 32-084 was similar to but less potent than CH 29-717, while 32-085, the l-methyl derivative, showed delayed dopaminomimeti...

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Veröffentlicht in:	Experientia 1979-12, Vol.35 (12), p.1677-1678
Hauptverfasser:	Flückiger, E, Briner, U, Bürki, H R, Marbach, P, Wagner, H R, Doepfner, W
Format:	Artikel
Sprache:	eng
Schlagworte:	3,4-Dihydroxyphenylacetic Acid - metabolism Animals Corpus Striatum - drug effects Corpus Striatum - metabolism Dopamine - metabolism Embryo Implantation - drug effects Ergolines - pharmacology Female Lactation - drug effects Pregnancy Prolactin - metabolism Rats Structure-Activity Relationship
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Zusammenfassung:	Prolactin secretion inhibition and changes in striatal dopamine metabolism in rats were compared after the administration of 8 alpha-amino-ergoline CH 29-717 and 2 derivates. CQ 32-084 was similar to but less potent than CH 29-717, while 32-085, the l-methyl derivative, showed delayed dopaminomimetic effects.
ISSN:	0014-4754 1420-9071
DOI:	10.1007/BF01953267