Inhibition of pig kidney dopa decarboxylase by coenzyme-5-hydroxytryptophan adducts

The effect of N-(5'-phosphopyridoxyl)-L-5-hydroxytryptophan, N-(5'-phosphopyridoxyl)-D-5-hydroxytryptophan and N-(5'-phosphopyridoxyl)-5-hydroxytryptamine on the reactivation of apoDopa decarboxylase to holoenzyme has been investigated. The different degree of inhibition exerted by th...

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Veröffentlicht in:	Experientia 1984-08, Vol.40 (8), p.834-835
Hauptverfasser:	DOMINICI, P, CURINI, M, MINELLI, A, VOLTATTORNI, C. B
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoenzymes - antagonists & inhibitors Apoproteins - antagonists & inhibitors Aromatic Amino Acid Decarboxylase Inhibitors Biological and medical sciences Enzyme Activation - drug effects Enzyme Reactivators Fundamental and applied biological sciences. Psychology Kidney - enzymology Pyridoxal Phosphate Serotonin - analogs & derivatives Swine Vertebrates: urinary system
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Zusammenfassung:	The effect of N-(5'-phosphopyridoxyl)-L-5-hydroxytryptophan, N-(5'-phosphopyridoxyl)-D-5-hydroxytryptophan and N-(5'-phosphopyridoxyl)-5-hydroxytryptamine on the reactivation of apoDopa decarboxylase to holoenzyme has been investigated. The different degree of inhibition exerted by these adducts has been interpreted on the basis of a different orientation of the 2 isomers of 5-HTP at the active of Dopa decarboxylase.
ISSN:	0014-4754 1420-9071
DOI:	10.1007/BF01951979