Metabolism of 3 beta-hydroxycholest-5-en-26-oic acid in hamsters

Metabolism of 26-hydroxycholesterol to 3 beta-hydroxychol-5-en-24-oic acid and other C24-bile acids has been expected to occur by way of 3 beta-hydroxycholest-5-en-26-oic acid in studies in vitro. 3 beta-Hydroxycholest-5-en-26-oic acid was infused intravenously into bile fistula hamsters and the fol...

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Veröffentlicht in:	Experientia 1990-03, Vol.46 (3), p.267-269
Hauptverfasser:	Ayaki, Y, Kok, E, Javitt, N B
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bile - metabolism Bile Acids and Salts - metabolism Cholesterol - analogs & derivatives Cholesterol - metabolism Chromatography, High Pressure Liquid Chromatography, Thin Layer Cricetinae Male Mesocricetus Radioisotope Dilution Technique
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Zusammenfassung:	Metabolism of 26-hydroxycholesterol to 3 beta-hydroxychol-5-en-24-oic acid and other C24-bile acids has been expected to occur by way of 3 beta-hydroxycholest-5-en-26-oic acid in studies in vitro. 3 beta-Hydroxycholest-5-en-26-oic acid was infused intravenously into bile fistula hamsters and the following C24-bile acids were identified: 3 beta-hydroxychol-5-en-24-oic acid, lithocholic acid, chenodeoxycholic acid, and a small amount of cholic acid.
ISSN:	0014-4754 1420-9071
DOI:	10.1007/BF01951761