Pharmacologic therapeutic window of pramiracetam demonstrated in behavior EEG, and single neuron firing rates

Pharmacologic therapeutic window of pramiracetam demonstrated in behavior EEG, and single neuron firing rates

Following oral or intravenous administration, a representative cognition activator drug, pramiracetam sulfate, is shown to have a pharmacologic therapeutic window at three different levels of study: learned behavior, gross EEG activity of the frontal cortex and hippocampus, and firing rate of single...

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Veröffentlicht in:Experientia 1985-09, Vol.41 (9), p.1153-1156
Hauptverfasser: POSCHEL, B. P. H, HO, P. M, NITEMAN, F. W, CALLAHAN, M. J
Format: Artikel
Sprache:eng
Schlagworte:
Administration, Oral
Animals
Behavior, Animal - drug effects
Biological and medical sciences
Electroencephalography
Electrophysiology
General aspects
Injections, Intravenous
Learning - drug effects
Male
Medical sciences
Neurons - drug effects
Neurons - physiology
Neuropharmacology
Pharmacology. Drug treatments
Physostigmine - pharmacology
Pyrrolidines - therapeutic use
Rats
Rats, Inbred F344
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Beschreibung
Zusammenfassung:Following oral or intravenous administration, a representative cognition activator drug, pramiracetam sulfate, is shown to have a pharmacologic therapeutic window at three different levels of study: learned behavior, gross EEG activity of the frontal cortex and hippocampus, and firing rate of single hippocampal neurons.
ISSN:0014-4754
1420-9071
DOI:10.1007/BF01951704