Schistosoma mansoni; Activity responses in vitro to praziquantel

The effects of praziquantel, a novel antischistosomal compound, on the activity of adult Schistosoma mansoni (Liverpool strain) in vitro were investigated. Worm activity was modified at all concentrations of praziquantel. High concentrations (above 0.5 microgram/ml) produced rapid paralysis, whilst...

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Veröffentlicht in:	Zeitschrift fuer Parasitenkunde (Germany, F.R.) F.R.), 1979-06, Vol.58 (2), p.169-174
Hauptverfasser:	Chavasse, C.J. (Liverpool School of Tropical Medicine (UK). Dept. of Tropical Medicine), Brown, M.C, Bell, D.R
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Dose-Response Relationship, Drug In Vitro Techniques Isoquinolines - pharmacology Pyrazines - pharmacology Schistosoma mansoni - drug effects Schistosomicides - pharmacology Solutions Time Factors
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Zusammenfassung:	The effects of praziquantel, a novel antischistosomal compound, on the activity of adult Schistosoma mansoni (Liverpool strain) in vitro were investigated. Worm activity was modified at all concentrations of praziquantel. High concentrations (above 0.5 microgram/ml) produced rapid paralysis, whilst low concentrations of praziquantel stimulated worm activity. It is concluded that such activity modification could lead to worm displacement in vivo.
ISSN:	0044-3255 1432-1955
DOI:	10.1007/BF01951341