Biotin as a regulator of some haematic parameters and of DNA-content of the liver of old rats

Biotin administration to old rats (28 months) causes in the blood an increase of ATP, glucose, triglycerides, alkaline phosphatase and a decrease of cholesterol and acid phosphatase; in the liver DNA and electrostatic interactions between DNA and histones are increased. Such parameters come within t...

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Veröffentlicht in:	Experientia 1978-02, Vol.34 (2), p.193-195
Hauptverfasser:	Petrelli, F, Coderoni, S, Moretti, P, Marsili, G, Paparelli, M
Format:	Artikel
Sprache:	eng
Schlagworte:	Acid Phosphatase - blood Adenosine Triphosphate - blood Aging Alkaline Phosphatase - blood Animals Biotin - pharmacology Blood Glucose - analysis Blood Glucose - metabolism Blood Proteins - analysis Blood Proteins - metabolism Cholesterol - blood Deoxyribonucleoproteins - analysis Deoxyribonucleoproteins - metabolism DNA - analysis DNA - metabolism Female Lipids - blood Liver - analysis Liver - drug effects Liver - metabolism Metabolism - drug effects Rats Triglycerides - blood
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Zusammenfassung:	Biotin administration to old rats (28 months) causes in the blood an increase of ATP, glucose, triglycerides, alkaline phosphatase and a decrease of cholesterol and acid phosphatase; in the liver DNA and electrostatic interactions between DNA and histones are increased. Such parameters come within the values shown by adult rats.
ISSN:	0014-4754 1420-9071
DOI:	10.1007/BF01944672