Infusion of a novel peptide, PHI, in man. Pharmacokinetics and effect on gastric secretion

Infusion of a novel peptide, PHI, in man. Pharmacokinetics and effect on gastric secretion

PHI, infused in man, achieved plateau plasma levels of 297 pmoles/1. The plasma half life was 3.1 min, metabolic clearance rate was 16.4 ml/kg/min and estimated volume of distribution was 73.2 ml/kg. No subjective side effects were noted during the infusion and there was no significant alteration in...

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Veröffentlicht in:Experientia 1983-10, Vol.39 (10), p.1129-1131
Hauptverfasser: ALLEN, J. M, CHRISTOFIDES, N. D, GORNACZ, G, TATEMOTO, K, BARON, J. H, BLOOM, S. R
Format: Artikel
Sprache:eng
Schlagworte:
Adult
Biological and medical sciences
Digestive system
Gastric Acid - metabolism
Humans
Kinetics
Male
Medical sciences
Pentagastrin - pharmacology
Pepsin A - metabolism
Peptide PHI
Peptides - metabolism
Pharmacology. Drug treatments
Time Factors
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Zusammenfassung:PHI, infused in man, achieved plateau plasma levels of 297 pmoles/1. The plasma half life was 3.1 min, metabolic clearance rate was 16.4 ml/kg/min and estimated volume of distribution was 73.2 ml/kg. No subjective side effects were noted during the infusion and there was no significant alteration in submaximal pentagastrin stimulated gastric acid or pepsin secretion.
ISSN:0014-4754
1420-9071
DOI:10.1007/BF01943143