Immunoquantitation of some cytochrome P-450 isozymes in liver microsomes from streptozotocin-diabetic rats

Immunoquantitation of some cytochrome P-450 isozymes in liver microsomes from streptozotocin-diabetic rats

Streptozotocin-diabetes in rats leads to a decrease of cytochrome P-450 UT-A (the major form in control rats) and an increase of cytochrome P-450 PB-B (the major one induced by phenobarbital treatment) in liver microsomes. The increased benzphetamine-N-demethylase activity can be related to the indu...

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Veröffentlicht in:Experientia 1986-10, Vol.42 (10), p.1162-1163
Hauptverfasser: ROUER, E, BEAUNE, P, LEROUX, J. P
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Biological and medical sciences
Cytochrome P-450 Enzyme System - metabolism
cytochrome P450
diabetes mellitus
Diabetes Mellitus, Experimental - enzymology
Diabetes. Impaired glucose tolerance
Endocrine pancreas. Apud cells (diseases)
Endocrinopathies
Immunoassay
Isoenzymes - metabolism
liver
Male
Medical sciences
microsomes
Microsomes, Liver - enzymology
Rats
Rats, Inbred Strains
streptozotocin
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Zusammenfassung:Streptozotocin-diabetes in rats leads to a decrease of cytochrome P-450 UT-A (the major form in control rats) and an increase of cytochrome P-450 PB-B (the major one induced by phenobarbital treatment) in liver microsomes. The increased benzphetamine-N-demethylase activity can be related to the induction of cytochrome P-450 PB-B.
ISSN:0014-4754
1420-9071
DOI:10.1007/BF01941293