Effect of acetylhomocysteine thiolactone on nucleolar cytology and lipofuscinogenesis in electric lobe neurons

Treatment with acetylhomocysteine thiolactone significantly reduces the cellular level of lipofuscin in neurons of the electric lobe of Torpedo marmorata. At the same time, this drug produces a 45% decrease in nucleolar volume in these neurons, reflecting decreased cellular synthetic activity.

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Bibliographische Detailangaben
Veröffentlicht in:	Experientia 1988-08, Vol.44 (8), p.712-713
Hauptverfasser:	ENESCO, H. E, ENESCO, M. A, TOTARO, E. A, PISANTI, F. A
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Cell Nucleolus - drug effects Cell Nucleolus - ultrastructure Electric Organ - drug effects Electric Organ - ultrastructure General and cellular metabolism. Vitamins lipofuscin Lipofuscin - metabolism Marine Medical sciences Pharmacology. Drug treatments Pigments, Biological - metabolism Thiophenes - pharmacology Torpedo Torpedo marmorata
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Beschreibung
Zusammenfassung:	Treatment with acetylhomocysteine thiolactone significantly reduces the cellular level of lipofuscin in neurons of the electric lobe of Torpedo marmorata. At the same time, this drug produces a 45% decrease in nucleolar volume in these neurons, reflecting decreased cellular synthetic activity.
ISSN:	0014-4754 1420-9071
DOI:	10.1007/BF01941039