Development of high blood pressure in spontaneously hypertensive rats is delayed by treatment with cyclosporin at an early age

Development of high blood pressure in spontaneously hypertensive rats is delayed by treatment with cyclosporin at an early age

In spontaneously hypertensive rats the effect of the T-cell inhibitor cyclosporin was studied at different ages. If treatment was started at the age of 2 weeks the development of hypertension was delayed, but the ultimate level of blood pressure was not affected. These results indicate the involveme...

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Veröffentlicht in:Experientia 1987-04, Vol.43 (4), p.403-405, Article 403
Hauptverfasser: SITSEN, J. M. A, DE JONG, W
Format: Artikel
Sprache:eng
Schlagworte:
Aging - physiology
Animals
Antihypertensive agents
Biological and medical sciences
Cardiovascular system
Cyclosporins - pharmacology
Hypertension - immunology
Male
Medical sciences
Pharmacology. Drug treatments
Rats
Rats, Inbred SHR
Rats, Inbred WKY
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Zusammenfassung:In spontaneously hypertensive rats the effect of the T-cell inhibitor cyclosporin was studied at different ages. If treatment was started at the age of 2 weeks the development of hypertension was delayed, but the ultimate level of blood pressure was not affected. These results indicate the involvement of immune mechanisms in the early development of hypertension in spontaneously hypertensive rats.
ISSN:0014-4754
1420-9071
DOI:10.1007/BF01940428